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KMID : 0980720160350010044
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Keimyung Medical Journal
2016 Volume.35 No. 1 p.44 ~ p.49
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Autoimmune Hepatitis-systemic Lupus Erythematosus Overlap Syndrome Diagnosed after Tapering Immunosuppressive Therapy
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Lee Bho-Hyeon
Park Seung-Ah
Kim Joo-Kyung
Cheon Dae-Young
Kang Seong-Hun
Choi Nan-Young
Park Ji-Won
Kwon Mi-Jung
Seo Young-Il
Kim Sung-Eun
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Abstract
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The differential diagnosis of systemic lupus erythematosus (SLE) and autoimmune hepatitis (AIH) is difficult due to the resemblance of these two disorders. However, the accurate diagnosis is important for prognosis and treatment that are different from each other. We report a case of AIH-SLE overlap syndrome which tapering of prednisone and azathioprine therapy deteriorated the condition of a patient due to flare up of SLE. The patient was a 28-year-old woman diagnosed as AIH. After administrations of prednisone and azathioprine, her condition was improved. During dose reduction, she was admitted to our hospital as fever and dyspnea. She diagnosed as lupus nephritis. After high dose treatment with orticosteroids and azathioprine, she recovered. Once the diagnosis of autoimmune disease such as SLE or AIH has been made, clinicians should also be fully aware of concomitant other autoimmune disease.
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KEYWORD
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Autoimmune hepatitis, Overlap syndrome, Systemic lupus erythematosus
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